Overview
The Sepax C-Pro Cell Processing System, which is comprised of the instrument, Sepax C-Pro protocol software, and kits, allows you to combine multiple processing steps in a versatile manner. These steps include but are not limited to enrichment, magnetic bead incubation, spinoculation, concentration, washing, dilution, and splitting.
Product overview
Cell therapy applications. The Sepax C-Pro Cell Processing Instrument has been used to prepare CAR T cells, natural killer cells (NK cells), and other cell types. Sepax C-Pro can be part of a robust CAR T cell manufacturing workflow that is adaptable for cGMP compliance in production of clinically relevant doses. In a natural killer cell manufacturing workflow the Sepax C-Pro system was used with BeadWash C-Pro protocol software to functionally close and automate incubation with magnetic beads for CD3 depletion and CD56 selection. These steps were included in a workflow with xeno-free expansion that generated 1 × 109 primary human NK cells and can be adapted for GMP compliance.
Instrument flexibility. In combination with the appropriate protocol software and single-use kit, the instrument can perform the following operations:
Concentrate cells from fresh apheresis product via plasma depletion
Concentrate cells and remove platelets from fresh apheresis units
Incubate magnetic beads onto the cell fractions obtained from apheresis units – sequence concentration, platelet depletion, bead incubation, and washing
Enrich mononuclear cells fraction via a density gradient medium
Concentrate, wash, and transduce isolated cells by spinoculation
Dilute, concentrate, and wash fresh or frozen cellular product
Dilute and split cellular products into multiple bags for accurate dosing
Learn more about Sepax C-Pro Cell Processing System
Overview
The Sepax C-Pro Cell Processing System, which is comprised of the instrument, Sepax C-Pro protocol software, and kits, allows you to combine multiple processing steps in a versatile manner. These steps include but are not limited to enrichment, magnetic bead incubation, spinoculation, concentration, washing, dilution, and splitting.
Product overview
Cell therapy applications. The Sepax C-Pro Cell Processing Instrument has been used to prepare CAR T cells, natural killer cells (NK cells), and other cell types. Sepax C-Pro can be part of a robust CAR T cell manufacturing workflow that is adaptable for cGMP compliance in production of clinically relevant doses. In a natural killer cell manufacturing workflow the Sepax C-Pro system was used with BeadWash C-Pro protocol software to functionally close and automate incubation with magnetic beads for CD3 depletion and CD56 selection. These steps were included in a workflow with xeno-free expansion that generated 1 × 109 primary human NK cells and can be adapted for GMP compliance.
Instrument flexibility. In combination with the appropriate protocol software and single-use kit, the instrument can perform the following operations:
Concentrate cells from fresh apheresis product via plasma depletion
Concentrate cells and remove platelets from fresh apheresis units
Incubate magnetic beads onto the cell fractions obtained from apheresis units – sequence concentration, platelet depletion, bead incubation, and washing
Enrich mononuclear cells fraction via a density gradient medium
Concentrate, wash, and transduce isolated cells by spinoculation
Dilute, concentrate, and wash fresh or frozen cellular product
Dilute and split cellular products into multiple bags for accurate dosing
Learn more about Sepax C-Pro Cell Processing System
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